CHARACTERISTICS OF RENAL CANCER PATIENTS IN HAJI ADAM MALIK GENERAL HOSPITAL MEDAN IN THE YEAR 2011 -2015

Riyan Adi Kurnia, Dhirajaya Dharma Kadar, Fauriski Febrian Prapiska

Abstract


Objective: The aim of this study is to identity the characteristics of kidney cancer patients at Haji Adam Malik Hospital between 2011 and 2015. Material & methods: This is a retrospective descriptive study of all kidney cancer patients treated at Haji Adam Malik Hospital between 2011 and 2015. Individual patient data was collected from medical record and compiled. Results: Between 2011 and 2015, there were 38 patients diagnosed with kidney cancer treated at Haji Adam Malik Hospital. The patients mean age is 48.26 ± 14.68 years, with a male to female ratio 1.7:1. Histological type found in the study was RCC (57.15%), urothelium based (19.05%), sarcoma variant (14.28%) and benign kidney tumor (9.52%). Clear cell RCC (58.3%) is the most common type of RCC. Based on the TNM classification, patients with kidney tumor of stage II, stage III and stage IV are 15.8%, 10.5% and 73.7% respectively. The treatment modalities for kidney cancer are nephrectomy (44.7%), nephroureterectomy (2.6%), biopsy (8.0%) and inoperable patients or treatment refusal (44.7%). The mortality rate of kidney cancer patients was 81.5%. Conclusion: Mean age of kidney cancer patients at Haji Adam Malik Hospital was lower than that reported in literature. Gender ratio was found similar as seen in literature. The ratio of histological type was differ, but we still found RCC as the most common type of kidney malignancies. Higher number of patients presented at advance stage at diagnosis and refusal to treatment may contribute to the high mortality rate in this study.



Keywords


kidney cancer

Full Text:

PDF

References


International Agency for Research on Cancer. Globocan 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012. Download from www.globocan.iarc.fr/Pages/fact_sheets_population.aspx

Colli J, Busby J, Amling C. Renal cell carcinoma rates compared with health status and behavior in the United States. J Urol. 2009; 73: 431-6.

Lipworth L, Tarone RE, McLaughlin JK. The epidemiology of renal cell carcinoma. J Urol. 2006; 176: 2353-8.

Chow W, Devesa S, Warren J. Rising incidence of renal cell cancer in the United States. JAMA. 1999; 281: 1628-31.

Pantuck AJ, Zisman A, Belldegrun AS. The changing natural history of renal cell carcinoma. J Urol. 2001; 166: 1611-23.

Ljunberg B, Campbell SC, Cho HY. The epidemiology of renal cell carcinoma. Eur Urol. 2011; 60: 615-21.

Weikert S, Boeing H, Pischon T. Fruits and vegetables and renal cell carcinoma: Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer. 2006; 118: 3133-9.

Daniel C, Cross A, Graubard B. Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma. Am J Clin Nutr. 2012; 95: 155-62.

Bellocco R, Pasquali E, Rota M. Alcohol drinking and risk of renal cell carcinoma: Results of a meta-analysis. Annals of Oncol. 2012; 23: 2235-44.

Song D, Song S, Song Y. Alcohol intake and renal cell cancer risk: A meta-analysis. Brit J Cancer; 2012.

Srigley J, Delahunt B, Eble J. The International Society of Urology Pathology (ISUP) Vancouver Classification of Renal Neoplasia. Am J Surg Pathol. 2013; 37: 1469-89.

Steffens S, Janssen M, Roos F. Incidence and long-term prognosis of papillary compared to clear renal cell carcinoma – A multicentre study. Eur J Cancer. 2012; 48: 2347-52.

Volpe A, Novara G, Antonelli A. Chromophobe renal cell carcinoma (RCC): Oncological outcomes and prognostic factors in a large multicentre series. BJUI. 2011; 110(1): 76-83.

Hunt JD, van der Hel OL, McMillan GP. Renal cell carcinoma in relation to cigarette smoking: Meta-analysis of 24 studies. Int J Cancer. 2005; 114: 101-8.

Renehan AG, Tyson M, Egger M. Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies. Lancet. 2008; 371: 569-78.

Chow WH, Gridley G, Fraumeni JF. Obesity, hypertension, and the risk of kidney cancer in men. N Engl J Med. 2000; 343: 1305-11.

Tsui KH, Shvarts O, Smith RB. Renal cell carcinoma: A prognostic significance of incidentally detected tumors. J Urol. 2000; 163(2): 426-30.

Guðmundsson E, Hellborg H, Lundstam S. Metastatic potential in renal cell carcinomas ≤7 cm: Swedish Kidney Cancer Quality Register Data. Eur Urol. 2011; 60: 975-82.

Bianchi M, Sun M, Jeldres C. Distribution of metastatic sites in renal cell carcinoma: A population-based analysis. Annals of Oncol; 2011.

Zini L, Perrotte P, Jeldres C. A population-based comparison of survival after nephrectomy vs nonsurgical management for small renal masses. BJUI. 2009; 103: 899-904.


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.