PENGARUH ISKEMIA TERHADAP PENINGKATAN KOLAGEN PADA KORPUS KAVERNOSUM
##plugins.themes.bootstrap3.article.main##
##plugins.themes.bootstrap3.article.sidebar##
Abstract
Objective: To demonstrate that ischemia causes elevation of collagen in cavernous body. Material & Method: Sample used in this study were male adult rabbits (Oryctalagus Cuniculus) 6 – 9 months of age. Partial ligation of both common iliac arteries was performed in this study to induce cavernous body ischemia. Results: Collagen mean for 7 x 24 hours ligation group (group B) increased to 113,83/200 compared to the collagen mean for the 2 x 24 hours ligation group (group A) which was 91,08/200 and collagen mean for control group (group C) which was 86,90/200. There was collagen elevation on treatment group which caused by ligation (Anova, F value= 12,110 and p=0,0001). Conclusion: Ischemia may elevate collagen in cavernous body.
##plugins.themes.bootstrap3.article.details##
Oryctalagus cuniculus, arterial ligation, corpus cavernosum
Albert B, Bray D, Lewis J, Raff M, Robberts K, Watson JD. Molecular biology of the cell. 3rd ed. Garland Publishing Inc; 1994. p. 977 – 85.
Leeson R, Leeson TS, Paparo AA, Text book of histology. Philadelphia: W.B. Saunders; 1985. p. 100 – 98.
Junqueira LC, Carneiro J, Kelley RO. Basic histology. 7th ed. Stamford: Appleton and Lange; 1992. p. 66 – 231.
Ganong WF. Review of medical physiology. 14th ed. Connecticut: Appleton and Lange; 1999. p. 60 – 79.
Cotran RS, Kumar V, Collins T. Robins: Pathologic basis of disease. 6th ed. Philadelphia: WB Saunders; 1999. p. 1 – 30.
Varga J, Rosenbloom J, Jimenez SA. Transforming growth factor-β (TGF-β) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblast. Biochem J 1987; 247: 597 – 604.
Moreland RB, Traish A, Mcmillin MA, Smith B, Goldstein I, De Tejada IS. PGE1 suppresses the induction of collagen synthesis by transforming growth factor-β1 in human corpus cavernosum smooth muscle. J Urol 1995; 153: 826 – 34.
Daley JT, Brown ML, Farber H, Saenz de Tejada L. Prostaglandin production during hypoxia in rabbit corpus cavernosum. J Urol 1993; 149: 285A, abstract 288.
Wespes E, Goes PM, Schiffmann S. Computerized analysis of smooth muscle fibers in potent and impotent patients. J Urol 1991; 146: 1015.
Virag R and Shoukry K. Re: computerized analysis of smooth muscle fibers in potent and impotent patients. Letter to the editor. J Urol 1992; 147: 896.
Hall SJ, Basile G, Bertero EB, de las Morenas A and Goldstein I. Extensive corporeal fibrosis after penile irradiation. J Urol 1995; 153: 372.
Nehra A, Hall SJ, Basile G, Bertero EB. Systemic sclerosis and impotence: A clinicopathological correlation. J Urol 1995; 153: 1140
Nehra A, Goldstein I, Pabby A. Mechanisms of venous leakage: A prospective clinicopathological correlation of corporeal function and structure. J Urol 1996; 156: 1320 – 9.
Penttinen RP, Kobayashi S, Bornstein P. Transforming growth factor increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stablity. Proc Natl Acad Sci USA. 1988; 83: 1105 – 8.
Azadzoi KM, Park K, Andry C, Goldstein I, Siroky MB. Relationship between cavernosal ischemia and corporal veno-occlusive dysfunction in an animal model. J Urol 1997; 157: 1011 – 7.
Azadzoi KM, Krane RJ, Goldstein I, Siroky MB. Ischemia induced alteration in cavernosal eicosanoids and TGF-β1 impairs nitric oxide pathway and relaxation of cavernosal tissue. Int J Impot Res 1996; 8: 107.
Jiaan DB. Age-related increase in an advanced glycation end product in penile tissue. World J Urol 1995; 13: 369 – 75.
Akkus E. Structural alterations in the tunica albuginea of the penis: impact of Peyronie’s disease, ageing and impotence. Br J Urol Int 1997; 79: 47 – 53.
Tarcan T, Azadzoi KM, Siroky MB. Age-related erectile and voiding dysfunction: the role of arterial insufficiency. Br J Urol; 82 (Suppl.1): 26 – 33.
Moreland RB. Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the society for the study of Impotence. Int J Impot Res 1998; 10: 113 – 20.
Dahiya R. Differential gene expression of growth factors in young and old rat penile tissues is associated with erectile dysfunction. Int J Impot Res 1999; 11: 201 – 6.
Rote NS. Inflammation. In: McCance KL, Huether SE (eds). Pathophysiology: The biologic basis for disease in adults and children. 2nd ed. Baltimore: Mosby. p. 234 – 67.