COMPARISON BETWEEN GLYCOGEN LEVEL OF KIDNEY TUBULAR CELLS IN DIABETIC KIDNEY STONE PATIENTS AND NON DIABETIC KIDNEY STONE PATIENTS

Ken Ramadhan, Suwandi Sugandi, Bambang S Noegroho, Tjahjodjati Tjahjodjati, Ferry Safriadi, Safendra Siregar, Ricky Adriansjah, Kuncoro Adi, Aaron Tigor Sihombing, Makmuri Yusuf

Abstract


Objective: To compare glycogen level of kidney tubular cells in diabetic kidney stone patients with nondiabetic kidney stone patients. Material & method: We reviewed kidney stone patients who underwent nephrectomy in Hasan Sadikin Hospital from February 2008 to January 2009. Age, gender, type of DM, and urine pH were recorded. Glycogen level of kidney tubular cells were evaluated histochemically using HE, PAS, and PAS diastase. The results were categorized into 3 grades, based on the staining appearance compared to liver cells as controls. The results of diabetic group were compared to non diabetic patients. Results: There were 30 patients eligible for this study, 15 in diabetic group and 15 non diabetic patients. In the diabetic group, there were 10 patients with urine pH < 6 and 5 patients with a pH of 6,5. In the non diabetic group all urine pH were > 6,5. Examination revealed that glycogen level of kidney tubular cells in diabetic group was higher than in non diabetic group. Conclusion: Glycogen level of kidney tubular cells in diabetic kidney stone patients was higher than in non diabetic kidney stone patients.

Keywords: Tubular cell, kidney stone, diabetes mellitus.

Full Text:

Untitled

References


Hruska KA, Seltzer JR, Grieff M. Nephrolithiasis. In: Diseases of The Kidney. 6th ed. Boston: Little, Brown and Company; 2002. p. 740-1.

Curhan GC, Stampfer MJ, Taylor EN. Diabetes mellitus and the risk of nephrolithiasis. Kidney Int 2005; 68: 1230–5.

Assimos DG. Diabetes mellitus and kidney stone formation. Rev Urol 2006; 8 (1): 44.

Lotan Y, Pearle MS. Urinary lithiasis: Etiology, epidemiology, and pathogenesis. In: Campbell-Walsh Urology. 9th Ed. Philadelphia: Saunders Elsevier; 2002. p. 1382-5.

Daudon M, Jungers P. Diabetes and nephrolithiasis. Current Diabetes Reports 2007; 7 (6): 1534.

Daudon M, Traxer O, Conrant P. Type 2 diabetes increases the risk for uric acid stones. Am Soc Nephrol 2006; 17: 2026.

Ngo TC, Assimos DG. Uric acid nephrolithiasis: Recent progress and future directions. Rev Urol 2007; 9 (1): 17-27.

Sakhaee K. Recent advances in pathophysiology of nephrolithiasis. Kidney Int 2009; 75 (6): 595.

Cameron MA. Urine composition in type 2 diabetes: Predisposition to uric acid nephrolithiasis. Am Soc Nephrol 2006; 17: 1422.

Bobulescu A. Effect of renal lipid accumulation on proximal tubule Na+/H+ exchange and ammonium secretion. Am J Physiol Renal Physiol 2008; 296: 1315.


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.