Isdianto Septiadi Suwandi Sugandi Bambang S Noegroho Tjahjodjati Tjahjodjati Ferry Safriadi Safendra Siregar Ricky Adriansjah Kuncoro Adi Aaron T Sihombing Sawkar V Pramod Ramlan Nasution Betthy S Hernowo


Objective: The aim of the study was to detect the differences in number and the distribution of angiotensin II type-1 receptor (AT1R) in BPH, high grade PIN, and adenocarcinoma of the prostate. Material & method: A prospective study was performed in RSHS, in collaboration with the Department of Anatomical Pathology. Prostate samples were taken by TUR of the prostate, and then divided into 5 groups. They were BPH, high grade PIN, adenocarcinoma of the prostate in 3 difference grades (well, moderate, and poorly differentiated). Kidney tissue for control. Immunohistochemical staining was done to determine the angiotensin II type-1 (AT1R) receptor distribution as primary antibody used was mouse monoclonal antibody AT1 (TONI-1): sc-57036, Santa Cruz Biotechnology Inc., CA. Results: Angiotensin II type-1 receptor was found in material of BPH, high grade PIN and adenocarcinoma of the prostate. The number and distribution of the receptors were not different. Conclusion: There are no significant differences in number and distribution of angiotensin II type-1 receptor on BPH, high grade PIN, and adenocarcinoma of the prostate.



Angiotensin II, high grade PIN, adenocarcinoma of the prostate


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July 2010 Vol. 17 No. 2
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Department of Urology, Faculty of Medicine/Airlangga University