Published 2022-04-28
Farid Sura Wijaya Untung Tranggono


Objective: The purpose of this study was to determine the expression of miRNA-92A in Bladder Cancer can be used as a marker of tumor. Material & Methods: This study used a total of 30 samples. 15 samples of non-invasive bladder cancer and 15 samples of muscle invasive bladder cancer. The sample was obtained in the Anatomical Pathology laboratory from January 2016 to December 2016. Tumor tissue then extracted miRNA-92A with a RT-PCR examination with Total miRNA Mini Kit FavorPrepTM. The result is done by Mann Whitney U test. Results: The mean expression of miRNA-92A in non-muscle invasive bladder cancer is 12.75 while in muscle invasive bladder cancer had an average value of 31.79. The Mann Whitney U test was used to evaluate the median difference between these groups. There was a significant difference in the expression of miRNA-92A in both groups with P = 0.000 (<0.005). Conclusion: There is a significant difference between the expression of miRNA-92A in non-muscle invasive bladder cancer compared to muscle invasive bladder cancer with more dominant expression on muscle invasive bladder cancer



Muscle invasive, bladder cancer, miRNA


Stephen, Jones. Non–Muscle-Invasive Bladder Cancer (Ta, T1, and CIS). in CAMPBELL-WALSH UROLOGY, edited by A. J. Wein. Philadelphia: Elsevier, Inc. 2016; p. 2205–22.

Metts MC, Melts JC, Milito SJ, and ThomasCR, et al. Bladder Cancer : A Review Of Diagnosis And Management. Journal of The National Medical Association. 2000; 285–94.

Enokida H, Yoshino H, Matsushita R, and Nakagawa M, et al. The Role of microRNAs in Bladder Cancer. Investigative and Clinical Urology 2016; 57(1): 60–76.

Ingelmo-torres M, Lozano JJ, Izquierdo L, Carrion A, Costa A, Costa M, et al. Urinary Cell microRNA-Based Prognostic Classifier for Non- Muscle Invasive Bladder Cancer. Oncotarget. 2017; (11): 18238–47

Hery T dan Rainy U. Pemeriksaan Rapid Urinary Bladder Cancer Antigen Untuk Deteksi Karsinoma Sel Transisional Buli Pada Populasi Indonesia. 2013; 7(2): 41–46.

Grizzle WE and Manne U. Micrornas Are Stable In Formalin-Fixed Paraffin-Embedded Archival Tissue Specimens Of Colorectal Cancers Stored For Up To 28 Years. NIH Public Access. 2013; (3): 1937–40.

Catto, James WF, et al. Distinct MicroRNA Alterations Characterize High- and Low-Grade Bladder Cancer. Cancer Res. 2009; (21): 8472–82.

Kresno SB. Micro-RNA Dan Implikasinya Pada Kanker.Indonesian Journal of Cancer 2011; 5(3): 1–9.

Wargasetia, TL. The Potential of MiRNAs as Biomarkers and Therapy Targets for Cancer. Journal of Medicine and Health. 2016; 1(3): 277–86.

Copyright Information
Department of Urology, Faculty of Medicine/Airlangga University