MIRNA-92A PROFILING IN MUSCLE INVASIVE AND NON-MUSCLE INVASIVE BLADDER CANCERS IN RSUP DR SARDJITO YOGYAKARTA

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Published 2022-04-28
Farid Sura Wijaya Untung Tranggono

Abstract

Objective: The purpose of this study was to determine the expression of miRNA-92A in Bladder Cancer can be used as a marker of tumor. Material & Methods: This study used a total of 30 samples. 15 samples of non-invasive bladder cancer and 15 samples of muscle invasive bladder cancer. The sample was obtained in the Anatomical Pathology laboratory from January 2016 to December 2016. Tumor tissue then extracted miRNA-92A with a RT-PCR examination with Total miRNA Mini Kit FavorPrepTM. The result is done by Mann Whitney U test. Results: The mean expression of miRNA-92A in non-muscle invasive bladder cancer is 12.75 while in muscle invasive bladder cancer had an average value of 31.79. The Mann Whitney U test was used to evaluate the median difference between these groups. There was a significant difference in the expression of miRNA-92A in both groups with P = 0.000 (<0.005). Conclusion: There is a significant difference between the expression of miRNA-92A in non-muscle invasive bladder cancer compared to muscle invasive bladder cancer with more dominant expression on muscle invasive bladder cancer


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Keywords

Muscle invasive, bladder cancer, miRNA

References

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Department of Urology, Faculty of Medicine/Airlangga University