Objective: To know the incidence of urinary tract infection (UTI) with different antibiotic prophylaxis for transrectal ultrasonography (TRUS) prostate biopsy. Material & Method: The study included 34 patients at Soetomo Hospital Surabaya, who were divided into 2 groups, each group consisting of 17 patients. In the first group patients received 1000 mg of ciprofloxacin orally, in the second group cefotaxime 1000 mg iv was given prior to biopsy. The two groups were compared in terms of UTI incidence as observed from the blood levels of leukocytes, C-reactive protein (CRP) and urine culture 3 days after the procedure. Results: Based on blood leukocyte levels, there was no statistically significant difference between the two groups (p = 0,74 and p = 0,42). So was the comparison of CRP levels. There was no other significant difference found (p = 0,53 and p = 0,27). From the results of urine culture, the ciprofloxacin group had positive urine culture results lower than the cefotaxime group (29,4% : 35,3%), although it was not statistically significant (p = 1,0). Conclusion: Based on the parameters of blood leukocytes levels, CRP and urine culture, there were no differences in the incidence of UTI after biopsy in the two groups.Keywords: TRUS prostate biopsy, UTI, ciprofloxacin, cefotaxime.
Reynard J, Brewster S, Biers S. Infections and inflamatory conditions. Oxford Handbook of Urology. 1st ed. Oxford University Press; 2006.
Schaeffer A, Schaeffer E. Infections of the urinary tract, infections and inflamation. Campbell-Walsh Urology. 9th ed. Philadelphia: Saunders-Elsevier; 2007 (8).
Povoa P, Almeida E, Moreira P, Fernandes A, Mealha R, Aragao A, et al. C–reactive protein as an indicator of sepsis. J Intensive Care Med. 1999; 24: 1052–6.
Povoa P. C–reactive protein: A valuable marker of sepsis. Intensive Care Med. 2002; 28: 235–43.
Nguyen H. Bacterial infections of the genitourinary tract. Smith’s General Urology. 17th ed. McGraw Hill; 2008. p. 193-218.
Alukal J, Mir J, Bergin C. Genitourinary Infection. Handbook of Urology: Diagnosis and Therapy. 3rd ed. Lippincott Williams & Wilkins; 2004. p. 206-31.
Klein EA, Platz EA, Thompson IM. Epidemiology, etiology, and prevention of prostate cancer. Campbell-Walsh Urology. 9th ed. Philadelphia: Saunders-Elsevier; 2007 (90).
Puig J, Darnell A, Bermudez P, Malet A, Serrate G, Bare M, et al. Transrectal ultrasound-guided prostate biopsy: Is antibiotic prophylaxis necessary? Eur Radiol. 2006; 16: 939-43.
Lindert K, Kabalin J, Terris M. Bacteremia and bacteriuria after transrectal ultrasound guided prostate biopsy. The Journal of Urology. 2000; 164: 76-80.
Webb N, Woo H. Antibiotic prophylaxis for prostate biopsy. BJU International. 2002; 89: 824-8.
Aron M, Rajeev, Gupta NP. Antibiotic prophylaxis for transrectal needle biopsy of the prostate: A randomized controlled study. BJU International. 2000; 85: 682-5.
Breslin J, Turner B, Faber R, Rhamy R. Anaerobic infection as a consequence of transrectal prostatic biopsy. J Urol. 1978; 120: 502-3.
Gasser T, Ebert S, Graversen P, Madsen P. Ciprofloxacin pharmacokinetics in patient with normal and impaired renal function. Antimicrobial Agents and Chemotheraphy; 1987. p. 709-12.
Bergan T, Dalhoff A, Rohwedder R. Pharmacokinetics of ciprofloxacin. Infection; 1988: 16(1).
Briffaux R, Coloby P, Bruyere F, Ouaki F, Pires C, Dore B, et al. One perioperative dose randomized against 3-day antibiotik prophylaxis for transrectal ultrasonography-guided prostate biopsy. BJU International. 2008; 103: 1069-73.
Burden HP, Ranasinghe W, Persad R. Antibiotics for transrectal ultrasonography-guided prostate biopsy: Are we practising evidence-based medicine? BJU International; 2008.
Kapoor D, Klimberg I, Malek G, Wegenke J, Cox C, Patterson L. Single dose oral ciprofloxacin versus plasebo for prophylaxis during transrectal prostate biopsy. Elsevier. 1998; 52: 552-8.
Betty A, Daniel F, Alice S. Enterobacteriaceae. Diagnostic Microbiology: Mosby. 1998; 37: 509–26.
Betty A, Daniel F, Alice S. Pseudomonas, burkholderia, and similar organism. Diagnostic Microbiology: Mosby. 1998; 31: 448–60.