THE ASSOCIATION OF URINARY SPECIFIC GRAVITY AND ACIDITY WITH UROLITHIASIS
AbstractObjective: This study aimed to know the association between urinary specific gravity and acidity with the formation of urolithiasis. Material & Methods: This retrospective descriptive study was conducted among proven urolithiasis patients reporting to the Kardinah Hospital, Tegal. The patient’s age, gender, anatomical sites of the stone, and biochemical parameters were obtained from the case records. The correlation of kidneys stone with specific gravity and pH changed according to anatomical sites of stone was analyzed by One way Anova. Results: The resulted show urinary stones patients with lower pH tend to have a higher probability of stone formation but not specific to its location. Higher pH values were found in the patient with urinary stones at the kidney, ureter, and also bladder. The average of specific gravity in ureter stone patients was lower than stones on other sites. One-way ANOVA shows no statistically significant difference in patient's urinary pH with stones on different sites, but there is a statistically significant difference in specific gravity examination (p<0.05) on ureter stone patients compared to other locations. There is a statistically significant difference (p=0.000) of urine specific gravity of ureter stone compared to other anatomical sites with the lower mean value. Conclusion: A decrease in urinary pH is associated with the risk of urinary stone formation. The specific gravity value of the patient’s urine with kidney and bladder stones is higher than the patient with ureter stones but there is no association of urine specific gravity toward the risk of urinary stone formation.
Rabie E, Halim A. Urolithiaisis in adults clinical and biochemical aspects. Saudi Med J. 2005; 26: 705-13
Tiselius HG, Ackermann D, Alken P, Buck C, Conort P, Gallucci M. Guidelines on urolithiasis. Eur Urol. 2001; 40: 362-71.
Kim H, Jo MK, Kwak C, Park SK, Yoo KY, Kang D, et al. Prevalence and epidemiologic characteristics of urolithiasis in Seoul, Korea. Urology. 2002; 59: 517-21.
Lee YH, Huang WC, Tsai JY, Lu CM, Chen WC, Lee MH, et al. Epidemiological studies on the prevalence of upper urinary calculi in Taiwan. Urol Int. 2002; 68: 172-7
National Aeronautics and Space Administration. Evidence book. Risk of renal stone formation. Houston: Lyndon B Johnson Space Center; 2008.
Fauci AS, Kasper DL, Longo DL, et al. Disorders of the kidney and urinary tract. Harrison’s principles of internal medicine. 17th Ed. New York: Mc Graw Hill Medical; 2008. p. 1741-1830.
Fuller CE, Threatte GA, Henry JB. Basic examination of urine. In Henry JB, editor. Clinical diagnosis and management by laboratory method. 20th Ed. Philadelphia: WB Saunders Co; 2001: 367-402.
Johri N, Cooper B, Robertson W, Choong S, Rickards D, Unwin R. An update and practical guide to renal stone management. Nephron Clin Pract. 2010; 116: 159-71.
Parks JH, Coe FL, Evan AP, Worcester EM. Urine pH in renal calcium stone formers who do and do not increase stone phosphate content with time. Nephrol Dial Transplant. 2009; 24: 130-6.
Atmani F, Khan SR. Quantification of proteins extracted from calcium oxalate and calcium phosphate crystals induced in vitro in the urine of healthy controls and stone-forming patients. Urol Int. 2002; 68: 54-9.
Parvin M, Shakhssalim N, Basiri A, Miladipour AH, Golestan B, Torbati PM, et al. The most important metabolic risk factors in recurrent urinary stone formers. Urol J. 2011; 8:99- 106
Litwin MS, Saigal CS. Urologic Diseases in America. Washington, DC, US Government Publishing Office, NIH Publication No. 04-5512, 2004; 283-316.
Fawzi A, Hani IB, Mosameh Y. Chemical Composition of Urinary Calculi in North Jordan. J Biol Sci. 2007; 7: 1290-2.
Sperling O. Uric acid nephrolithiasis. In: Wickham EA, Buck AC, editors. Renal tact stone- Metabolic basis and clinical practice. Edinburgh: Churchill Livingstone; 1990. p. 349-65.
Tiselius HG. Solution chemistry of supersaturation. In: Coe FL, Favus CY, Pak CC, editors. Kidney stones: Medical and surgical management. Lippincott-Reven: Philadelphia; 1996. p. 33-64.
Kumar A. Urine examination for calculogenic crystals- a newer approach using refrigeration. Trop Doct. 2004; 34: 153-5.
Robertson WG, Peacock M. The cause of idiopathic calcium stone disease: hypercalciuria or hyperoxaluria. Nephron. 1980; 26: 105-10
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