Objective: The purpose of this study is to examine the difference of lower urinary tract (LUT) symptoms in anuric and non-anuric individuals after renal transplantation (RT). Material & Methods: LUT function and symptoms were assessed in subjects who had undergone RT at Cipto Mangunkusumo General Hospital, Jakarta, from November 2016 to June 2017. Subjects were divided into anuric and non-anuric groups. We excluded patients with surgical complications that could not undergo uroflowmetry. Results: Thirty-two (21 male, 11 female) subjects were recruited in this study. The anuric subjects were younger than the non-anuric ones (47 ± 12.82 vs. 51.31 ± 16.33, p < 0.001) There were no significant differences in the International Prostate Symptoms Score (IPSS) (6.5 ± 3.67 vs. 6.25 ± 2.95, p = 0.567), Overactive Bladder Symptoms Score (OABSS) (4.06 ± 2.01 vs 4.12 ± 2.39, p = 1.000), maximum urinary flow rate (Qmax) (20.32 ± 9.04 vs. 22.32 ± 10.31, p = 0.956), post-void residual (PVR) (41.12 ± 37.63 vs. 47.62 ± 38.63, p = 0.361) and voided volume (227.88 ± 112.30 vs 251.06 ± 126.75, p = 0.588) between anuric and non-anuric subjects, respectively. IPSS-voiding symptom, IPSS-storage symptom, and OAB symptom did not differ significantly between both groups (p > 0.05). Thirteen (13/16) and seven (7/16) subjects of the anuric and non-anuric groups were both pleased with their quality of life, respectively. Conclusion: LUT symptoms do not differ between anuric and non-anuric patients.
Lower urinary tract symptoms, renal transplantation, anuria
Simsir A, Dheir H, Mammadov R, Hoscoskum C, Toz H, Ok E, et al. Evaluation of the lower urinary tract before renal transplantation: to which patients? how? Open J Urol. 2002; 2: 127–30.
Kasiske BL. The evaluation of prospective renal transplant recipients and living donors. Surgical Clinics of North America; 1998. p. 27–39.
Rigamonti W, Capizzi A, Zacchello G, Capizzi V, Zanon GF, Montini G, et al. Kidney transplantation into bladder augmentation or urinary diversion: Long-term results. Transplantation. 2005; 80(10): 1435–40.
Mendizabal S, Estornell F, Zamora I, Sabater A, Ibarra FG, Simon J. Renal transplantation in children with severe bladder dysfunction. J Urol. 2005; 173(1): 226–9.
Van der Weide MJA, Cornelissen EAM, Van Achterberg T, Smits JPJM, Feitz WFJ. Dysfunction of lower urinary tract in renal transplant children with nephrologic disease. Urology. 2006; 67(5): 1060–5.
Castagnetti M, Zhapa E, Berrettini A, Ghirardo G, Murer L, Zanon GF, et al. Lower urinary tract symptoms (LUTS) after renal transplant in non-urologic anuric patients. Pediatric Transplantation; 2010. p. 859–62.
van der Weide MJ, Hilbrands LB, Bemelmans BL, Meuleman EJ, Frederiks CM. Lower urinary tract symptoms after renal transplantation. J Urol. 2001; 166(4): 1237–41.
Herthelius M, Oborn H. Bladder dysfunction in children and adolescents after renal transplantation. Pediatr Nephrol. 2006; 21(5): 725–8.
Herthelius M, Oborn H. Urinary tract infections and bladder dysfunction after renal transplantation in children. J Urol. 2007; 177(5): 1883–6.
Mitsui T, Shimoda N, Morita K, Tanaka H, Moriya K, Nonomura K. Lower urinary tract symptoms and their impact on quality of life after successful renal transplantation. Int J Urol. 2009; 16(4): 388–92.
Mizerski A, Ostrowska Clark K, Ostrowski M, Ciechanowski K, Kaminski M, Sulikowski J, et al. Postoperative adaptation of urinary bladder to variable volume of urine in the initial period following kidney transplantation. In: Transplantation Proceedings; 2003. p. 2174–5.
Serrano DP, Flechner SM, Modlin CS, Wyner LM, Novick AC. Transplantation into the long-term defunctionalized bladder. J Urol. 1996; 156(3): 885–8.
Errando C, Batista JE, Caparros J, Vicente J, Arañó P. Urodynamic Evaluation and Management prior to Renal Transplantation. Eur Urol. 2000; 38(4): 415–8.
Zermann DH, Janitzky A, Höhne M, Schubert J. Frequency and nocturia after successful renal transplantation: A normal situation? BJU Int. 2006; 97(3): 555–8.
Van der Weide MJA, Hilbrands LB, Bemelmans BLH, Kiemeney LALM. Lower urinary tract symptoms after renal transplantation: are there changes over time? Urology. 2004; 63(3): 442–6.
Chun JM, Jung GO, Park JB, Choi GS, Kwon CHD, Joh JW, et al. Renal Transplantation in Patients With a Small Bladder. Transplant Proc. 2008; 40(7): 2333–5.
Martin X, Aboutaieb R, Soliman S, El Essawy A, Dawahra M, Lefrancois N. The use of long-term defunctionalized bladder in renal transplantation: Is it safe? Eur Urol. 1999; 36(5): 450–3.