EFFECT OF RED GINGER (Zingiber officinale Rosc. Var Rubrum) ETHANOL EXTRACT OR SILDENAFIL IN LIBIDO: A COMPARATIVE STUDY USING MALE WHITE RATS (Rattus norvegicus) MODEL WITH DIABETES MELLITUS
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Abstract
Objective: To compare the effect of red ginger ethanol extract and Sildenafil on increasing the libido of diabetic rat models and determine the dose that significantly affects the increase in libido of diabetic rat models. Materials & Methods: This study is an experimental was conducted on 30 male Sprague dawley white rats divided into 6 groups, namely normal control group, negative control group, sildenafil positive control group, 200 mg ginger group, 400 mg ginger group and 600 mg ginger groupstudy consisting of test animal groups: normal control group; negative control; positive control with sildenafil administration, and treatment groups consisting of: dose I (200mg/kgBB); dose II (400mg/kgBB) and, dose III (600mg/kgBB). All groups except the normal control received alloxan induction at the initial stage of testing. The effect of increasing the libido of rats is seen from sexual activity including: latency of copulation, latency of riding (climbing) and frequency of riding. Results: The results of this study indicate that the administration of red ginger ethanol extract at a dose of 400mg/kgBB or 600mg/kgBB has the same potential as sildenafil in increasing the libido of diabetic rat models. Conclusion: The administration of red ginger ethanol extract at a dose of 400mg/kgBB or 600mg/kgBB has the same potential as sildenafil in increasing the libido of diabetic rat models. Keywords: Red ginger, libido, diabetic rat models.
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Red ginger, libido, diabetic rat models.
Maiorino MI, Bellastella G, Esposito K. Diabetes and sexual dysfunction: Current perspectives. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2014.
Laumann EO, Nicolosi A, Glasser DB, Paik A, Gingell C, Moreira E, et al. Sexual problems among women and men aged 40-80 y: Prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. International Journal of Impotence Research. 2005.
Dohle GR, Diemer T, Kopa Z, Krausz C, Giwercman A, Jungwirth A. European Association of Urology guidelines on vasectomy. Actas Urológicas Españolas (English Edition). 2012;36(5):276-81.
Peyton CC, Colaco MA, Kovell RC, Kim JH, Terlecki RP. Erectile Dysfunction is Predictive of Endothelial Dysfunction in a Well Visit Population. Journal of Urology. 2016.
NHS UK. No Title [Internet]. 2020 [cited 2021 Feb 23]. Available from: https://www.nhs.uk/conditions/loss-of-libido/#:~:text=Loss of libido (sex drive, such as reduced hormone levels.
Hatzimouratidis K, Hatzichristou D. How to Treat Erectile Dysfunction in Men with Diabetes: from Pathophysiology to Treatment. Current Diabetes Reports. 2014.
Bokat G, Pickard R, Bartoletti R, Cai T, Bruyere F, Geerlings SE, et al. EAU Guidelines on Urological Infections - Limited update March 2018. European Association of Urology. 2018.
Enema OJ, Umoh UF, Umoh RA, Ekpo EG, Adesina SK, Eseyin OA. Chemistry and Pharmacology of Aphrodisiac Plants: A Review. Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research. 2018.
Ongwisespaiboon O, Jiraungkoorskul W. Fingerroot, Boesenbergia rotunda and its aphrodisiac activity. Pharmacognosy Reviews. 2017.
Singh R, Singh S, Jeyabalan, Ali A. An Overview on Traditional Medicinal Plants as Aphrodisiac Agent. Journal of Pharmacognosy and Phytochemistry. 2012.
Lim PHC. Asian herbals and aphrodisiacs used for managing ED. Translational Andrology and Urology. 2017.
Sutyarso, Busman H, Kanedi M, Muhartono. Rhizome Extract of White Ginger (Zingiber officinale Roxb) Maintains Testicular Function of Aging Mice. International Journal of Nutrition and Food Sciences. 2016;5(3):175
Ghlissi Z, Atheymen R, Ali Boujbiha M, Sahnoun Z, Ayedi FM, Zeghal K, et al. Antioxidant and androgenic effects of dietary ginger on reproductive function of male diabetic rats. International Journal of Food Sciences and Nutrition. 2013.
Sharma B, Siddiqui MohdS, Ram G, Yadav RK, Kumari A, Sharma G, et al. Rejuvenating of Kidney Tissues in Alloxan Induced Diabetic Mice under the Effect of Momordica charantia. Advances in Pharmaceutics. 2014.
Febriani Y et al. The Potential Use of Red Ginger (Zingiber officinale Roscoe) Dregs as Analgesic. Indonesian Journal of Pharmaceutical Science and Technology Journal Homepage. 2018.
Wardani IGAAK, Santoso P. Effectiveness of Afrodisiaka from Etanol Extract of Red Jahe (Zingiber officinale Roscoe) on Rats (Rattus norvegicus L.) Chicken. Medicamento Scientific Journal. 2017.
Rachmadi, A. Kadar Gula Darah dan Kadar Hormon Testosteron Pada Pria Penderita Diabetes Melitus Hubungannya Dengan Disfungsi Seksual dan Perbedaannya dengan yang Tidak Mengalami Disfungsi Seksual [tesis]. Universitas Diponegoro. Semarang. 2008.
Adimoelja A. Kesehatan Pria dan “Andropause” (PADAM). MAI:9:235-41.2004
Gorard DA. Escalating polypharmacy. QJM. 2006.
Malviya N, Jain S, Gupta VB, Vyas S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction - A review. Acta Poloniae Pharmaceutica - Drug Research. 2011.
Akinyemi AJ, Adedara IA, Thome GR, Morsch VM, Rovani MT, Mujica LKS, et al. Dietary supplementation of ginger and turmeric improves reproductive function in hypertensive male rats. Toxicology Reports. 2015.
Nurhanifah N, Sutyarso, Kanedi M, Busman H. Aggressiveness and libido of male Mus musculus L. in ethanol extract of red ginger (Zingiber officinale Roxb. var. Rubrum). Scientific Journal of Experimental Biology and Biodiversity. 2019.
Shabanian S, Ebrahimbabaei M, Safavi P, Lotfizadeh M. Comparing the effects of rose drop, ginger, and cinnamon on sexual function in depressed women with sexual dysfunction. Pharmacognosy Research. 2018.
Javaroni V, Neves MF. Erectile dysfunction and hypertension: Impact on cardiovascular risk and treatment. International Journal of Hypertension. 2012.