GIANT NON-FUNCTIONING ADRENOCORTICAL CARCINOMA
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Abstract
Objective: This study aims to report a case of a 51 year old male who was referred to our Department of Urology and was diagnosed with a nonfunctioning giant ACC. Case(s) Presentation: The case report describes a 51-year-old Indonesian man who presented to our department with complaints of persistent upper left abdomen discomfort, previously misdiagnosed as dyspepsia. He was diagnosed as having non-functioning adrenocortical carcinoma and underwent open adrenalectomy. Discussion: Although the patient is 51 years old and the tumor has grown to a signify cant size, no lymph node involvement or metastases was found and resection margins were found to be negative. In our patient, functional adrenal work-up results were normal. This has led us to suspect a non-functioning adrenal tumor. Metastatic work-up with CT cranial, chest, and bone survey were performed, with negative result. The biopsy result after resection confirmed the diagnosis of ACC. Conclusion: ACC is a rare aggressive tumor, malignant with poor prognosis. In our case, the non-secretory mass was diagnosed late by manifestation of mass effect symptoms in the upper left quadrant of the abdomen and was previously misdiagnosed as symptoms of dyspepsia. The functional work-up of adrenal masses helped in the determination of its non-functional status. Early diagnosis of ACC and early surgical excision helps in improving the overall survival rate of the patient. Keywords: Non-functioning, adrenocortical carcinoma (ACC), adrenalectomy, case report.
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Non-functioning, adrenocortical carcinoma (ACC), adrenalectomy, case report
Kostiainen I, Hakaste L, Kejo P, Parviainen H, Laine T, Löyttyniemi E, et al. Adrenocortical carcinoma: presentation and outcome of a contemporary patient series. Endocrine [Internet]. Springer US; 2019; 65(1): 166–74.
Bacalbasa N, Terzea D, Jianu V, Marcu M, Stoica C, Balescu I. Multiple visceral resection for giant non-secretory adrenocortical carcinoma in an elderly patient: A case report. Anticancer Res. 2015; 35(4): 2169–74.
George C, Ioannis P, Dimitra-Rafailia B, Dimitrios G, Alexandros K, Konstantinos I, et al. Giant nonfunctioning adrenal tumors: Two case reports and review of the literature. J Med Case Rep. Journal of Medical Case Reports; 2018; 12(1): 4–9.
Else T, Kim AC, Sabolch A, Raymond VM, Kandathil A, Caoili EM, et al. Adrenocortical carcinoma. Endocr Rev. 2014; 35(2): 282–326.
Bharwani N, Rockall AG, Sahdev A, Gueorguiev M, Drake W, Grossman AB, et al. Adrenocortical carcinoma: The range of appearances on CT and MRI. Am J Roentgenol. 2011; 196(6): 706–14.
Erickson LA. Challenges in surgical pathology of adrenocortical tumours. Histopathology. 2018; 72(1): 82–96.
Almarzouq A, Asfar S, Hussain S, Al-Hunayan A, Aldousari S. Giant nonfunctioning adrenocortical carcinoma: A case report and review of the literature. BMC Res Notes. 2014; 7(1).
Deandreis D, Leboulleux S, Caramella C, Schlumberger M, Baudin E. FDG PET in the management of patients with adrenal masses and Adrenocortical carcinoma. Horm Cancer. 2011; 2(6): 54–62.
Ayala-Ramirez M, Jasim S, Feng L, Ejaz S, Deniz F, Busaidy N, et al. Adrenocortical carcinoma: Clinical outcomes and prognosis of 330 patients at a tertiary care Center. Eur J Endocrinol. 2013; 169(6): 891–9.
Benassai G, Desiato V, Benassai G, Bianco T, Sivero L, Compagna R, et al. Adrenocortical carcinoma: What the surgeon needs to know. Case report and literature review. Int J Surg [Internet]. Elsevier Ltd; 2014; 12: S22–8.
Polavarapu. Adrenocortical Carcinoma: Complete Surgical Resection After 18 Years. World J Oncol. 2011; 2(6): 307–10.
De Francia S, Ardito A, Daffara F, Zaggia B, Germano A, Berruti A, et al. Mitotane treatment for adrenocortical carcinoma: an overview. Minerva Endocrinol. Italy; 2012 Mar; 37(1): 9–23.