CLINICOHISTOPATHOLOGICAL STUDY OF TESTICULAR TUMOURS IN DR. HASAN SADIKIN GENERAL HOSPITAL BANDUNG
##plugins.themes.bootstrap3.article.main##
##plugins.themes.bootstrap3.article.sidebar##
Abstract
Objective: The purpose of this research was to describe the clinical and histopathological characteristics of testicular tumours at Hasan Sadikin General Hospital (RSHS) between 2017-2021. Material & Methods: This research was a cross-sectional descriptive study examining the clinical and histopathological profiles of testicular tumours. The secondary data sources included medical records from the Department of Urology, Anatomic Pathology, Medical Records, and Hospital Information System (SIRS). The collected data covered age, ethnicity, clinical symptoms, site, stage, annual prevalence rate, and analyzed using Microsoft Excel. Results: There were 42 patients who had primary testicular tumour. The highest prevalence of testicular tumours at RSHS was in 2019 consist of 12(29%) patients and the lowest in 2020 were 6(14%) patients. Most patients were >35 years old amounting 19(45%) patients, Sundanese ethnicity were 29(69%) patients, and testicular enlargement revealed in 27(64%) patients. Majority patients were in stage 0/IB 36(86%) patients and occurred in unilateral testis which 34(80%) patients, with 3(7%) patients metastasized. The most common histopathological type was seminoma 18(43%) cases followed by prepubertal-type yolk sac tumour 9(21%) patients. Seminomas, and the fibroma-thecoma group were mostly in patients over 35 years old, while prepubertal-type yolk sac tumour was more commonly in children under 15 years old. Conclusion: Prevalence of testicular tumours increased from 2017 to 2019, then started to decrease in 2020. Histopathologically, seminoma was the most common type. These tumours were most commonly found in older individuals (>35 YO) and unilateral, diagnosed in stage 0/IB, and were mostly presented with enlargement of testis. Keywords: Testicular tumours, clinical features, histopathology
##plugins.themes.bootstrap3.article.details##
Testicular tumours, clinical features, histopathology
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3): 209–49.
Gurney JK, Florio AA, Znaor A, Ferlay J, Laversanne M, Sarfati D, et al. International Trends in the Incidence of Testicular Cancer: Lessons from 35 Years and 41 Countries. Eur Urol. 2019; 76(5): 615–23.
American Cancer Society. Cancer Facts & Figures 2023 | Testicular Cancer Statistics. Am Cancer Soc. 2023.
Znaor A, Skakkebæk NE, Rajpert-De Meyts E, Laversanne M, Kuliš T, Gurney J, et al. Testicular cancer incidence predictions in Europe 2010–2035: A rising burden despite population ageing. International Journal of Cancer. 2020; 147: 820–8.
Zahra AT. Karakteristik Klinis dan Histopatologis Tumor Testis di Bagian Patologi Anatomikk RSUP DR.Moh. Hoesin Palembang Tahun 2012-2016. FK Univ Sriwij. 2018.
Mukti AI, Hakim L, Djatisoesanto W, Hardjowijoto S. Testicular Cancer in Soetomo Hospital Surabaya: Retrospective Study. Indonesian Journal of Urology. 2018; 25.
Chaerul HA, Seputra KP, Daryanto B. Carcinoma testis profile in tertiary hospital 1. Indones J Urol. 2023; (2): 29–34.
Manecksha RP, Fitzpatrick JM. Epidemiology of testicular cancer. BJU Int. 2009 Nov; 104(9 Pt B): 1329–33.
Khetrapal S, Bhatia R. Impact of COVID-19 pandemic on health system & Sustainable Development Goal 3. Indian J Med Res. 2020 May 1; 151(5): 395–9.
Prabowo NA, Apriningsih H, Dirgahayu P, Ardyanto TD, Hanafi M, Indriani AT, et al. The Decrease in Hospital Visits at Universitas Sebelas Maret Hospital Due to the Level of Stress and Fear of COVID 19. Proc 4th Int Conf Sustain Innov 2020–Health Sci Nurs (ICoSIHSN 2020). 2021; 33(ICoSIHSN 2020): 101–4.
Chatsirisupachai K, Lesluyes T, Paraoan L, Van Loo P, de Magalhães JP. An integrative analysis of the age-associated multi-omic landscape across cancers. Nat Commun. 2021; 12(1): 1–17.
Winter C, Albers P. Testicular germ cell tumors: Pathogenesis, diagnosis and treatment. Nat Rev Endocrinol. 2011; 7(1): 43–53.
Secondino S, Rosti G, Tralongo AC, Nolè F, Alaimo D, Carminati O, et al. Testicular tumors in the “elderly” population. Front Oncol. 2022; 12(September): 1–6.
Yamashita S, Koyama J, Goto T, Fujii S, Yamada S, Kawasaki Y, et al. Trends in Age and Histology of Testicular Cancer from 1980-2019: A Single-Center Study. Tohoku J Exp Med. 2020; 252(3): 219–24.
Fabrianta DM, Seputra KP. Characteristic Chemotherapy Response of testicular Cancer. Indones J Urol. 2022; 208–11.
Otaguro K. Clinico-Pathological Study of Testicular Tumors. Japanese J Urol. 1958; 49(4): 297–348.
Goldblum, J. R., Lamps, L. W., McKenney, J., & Myers JL. Rosai and Ackerman’s Surgical Pathology E-Book. 10th ed. Elsevier Health Sciences; 2017.
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM. The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours. Eur Urol. 2016; 70(1): 93–105.